2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P3843
    Neuropeptide AF (cattle) 99588-52-0 98%
    Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC50 of ~60 nM) and MrgprC11 (EC50 of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC50 of ~25-325 nM) and NPFF2 (EC50 of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects.
    Neuropeptide AF (cattle)
  • HY-P3844
    Biotinyl-neuropeptide W-23 (human) 1815618-09-7 98%
    Biotinyl-neuropeptide W-23 (human) is a biotinylated Neuropeptide W-23 (human) (HY-P1035). Neuropeptide W-23 (human) is an agonist of NPBW1 (GPR7) and NPBW2 (GPR8).
    Biotinyl-neuropeptide W-23 (human)
  • HY-P3845
    (Gly22)-Amyloid β-Protein (1-42) 1802086-23-2 98%
    (Gly22)-Amyloid β-Protein (1-42) is a peptide fragment of amyloid β-protein (Aβ). Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease. Mutation of Glu22 to Gly22 in Aβ can increase aggregation.
    (Gly22)-Amyloid β-Protein (1-42)
  • HY-P3846
    (Glu20)-Amyloid β-Protein (1-42) 1802086-22-1 98%
    (Glu20)-Amyloid β-Protein (1-42) is a slower fibrillizing variant of amyloid β-protein (Aβ). The Glu20 mutation reduces the aggregation propensity of Aβ42 and prevents accumulation of the slowly fibrillizing peptide. Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease.
    (Glu20)-Amyloid β-Protein (1-42)
  • HY-P3847
    Tyr0-Neurokinin B 131019-53-9 98%
    Tyr0-Neurokinin B (Tyr-NKB) is an analogue of Neurokinin B. Tyr0-Neurokinin B can exerts contractions in bladder.
    Tyr0-Neurokinin B
  • HY-P3848
    Tyr0-Neurokinin A 116868-93-0 98%
    Tyr0-Neurokinin A is a neuropeptide belongs to tachykinin peptide family. Tyr0-Neurokinin A is an agonist of Tacr2. Tyr0-Neurokinin A can be used in the research of insulin resistance, obesity, diabetes.
    Tyr0-Neurokinin A
  • HY-P3850
    (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B 109212-72-8 98%
    (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B shows no influence on Substance P or Neurokinin A.
    (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B
  • HY-P3851
    (β-Ala8)-Neurokinin A (4-10) 127633-71-0 98%
    (β-Ala8)-Neurokinin A (4-10), a neuropeptide, is a potent and selective NK-2 tachykinin receptor (Neurokinin Receptor) agonist.
    (β-Ala8)-Neurokinin A (4-10)
  • HY-P3852
    Neurokinin Receptor (393-407), rat 153607-26-2 98%
    Neurokinin Receptor (393-407), rat (SPR393–407) is a rat neurokinin 1 receptor (NK1R) fragment. NK1R is rapidly internalized by endocytosis and recycled to the plasma membrane when binding to substance P (SP). Neurokinin Receptor (393-407), rat can be used in the research of neurogenic inflammation.
    Neurokinin Receptor (393-407), rat
  • HY-P3853
    GR 87389 141663-86-7 98%
    GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra.
    GR 87389
  • HY-P3854
    GR 83074 141636-44-4 98%
    GR 83074 is a potent and selective NK-2 (Neurokinin Receptor) antagonist with a pKB of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity.
    GR 83074
  • HY-P3856
    Endokinin C 347837-74-5 98%
    Endokinin C is a peptide component of endokinin. Endokinin C works as a neurotransmitter or modulator in the pain system. Pretreatment with endokinin C prevents induction of scratching behavior and thermal hyperalgesia of endokinin A/B in mice.
    Endokinin C
  • HY-P3857
    Carassin 133950-47-7 98%
    Carassin is a 21 amino acid tachykinin-related peptide, it can be isolated from the goldfish brain. Carassin has moderate affinity for rat tachykinin binding sites.
    Carassin
  • HY-P3858
    (D-Asp1)-Amyloid β-Protein (1-42) 1802086-19-6 98%
    (D-Asp1)-Amyloid β-Protein (1-42) is a peptide fragment of amyloid β-protein (Aβ). Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease.
    (D-Asp1)-Amyloid β-Protein (1-42)
  • HY-P3859
    Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42) 1802086-21-0 98%
    Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42) is a peptide fragment of amyloid β-protein (Aβ). Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42) can be used in research of Alzheimer's disease.
    Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42)
  • HY-P3860
    Biotinyl-Amyloid β-Protein (1-42) ammonium 98%
    Biotinyl-Amyloid β-Protein (1-42) ammonium is a biotinylated Amyloid β-Protein (1-42) (HY-P1363). Biotinyl-Amyloid β-Protein (1-42) ammonium can be used for the research of Aβ1-42 converts to Aβ1-40 in brain.
    Biotinyl-Amyloid β-Protein (1-42) ammonium
  • HY-P3861
    Biotin-NeurokininA 98%
    Biotin-NeurokininA is a biotinylated Neurokinin A (HY-P0197). Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.
    Biotin-NeurokininA
  • HY-P3869
    Lumekefamide 100304-60-7 98%
    Lumekefamide is a N-terminal shorter peptide amide of [D-Arg2]dermorphin with the hypothermic effect. Lumekefamide shows analgesic activity and degradation in soluble mouse liver and brain extracts.
    Lumekefamide
  • HY-P3870
    DALDA 118476-85-0 98%
    DALDA is a potent and highly selective μ-opioid receptor agonist with a Ki of 1.69 nM. DALDA shows antinociceptive and respiratory effects.
    DALDA
  • HY-P3871
    Peptide F, bovine 75718-92-2 98%
    Peptide F, bovine is a proenkephalin peptide F from in bovine brain and adrenal medulla. Enkephalinergic system involves in pain transmission.
    Peptide F, bovine
Cat. No. Product Name / Synonyms Application Reactivity